Curative effect of surgical resection in the treatment of Kaposiform
hemangioendothelioma
Abstract
Background The clinical features and surgical outcomes of patients with
Kaposiform hemangioendothelioma (KHE) is not fully clear. The purpose of
this study is to better understand the therapeutic effect and
hematological indices of surgical therapy for KHE. Procedure A
retrospective study was conducted to review the medical documents of 43
patients with KHE who were treated with surgical resection at our
hospital between February 2016 and November 2019. Multiple anatomical
sites were involved. The curative effect was evaluated according to the
tumor volume shrinkage, color shade, and blood examinations including
platelet count, hemoglobin level, red blood cell number, clotting time
and D-dimer concentration. Results For all cases underwent surgical
treatment, the curative effects accounted for 100%. At the end of the
treatment, 9 children were followed up for 6 months, and no evidence of
the recurrence of KHE was not found in any case. The number of red blood
cells and clotting time were maintained at normal levels during
different stage of treatment. The concentrations of hemoglobin and
fibrinogen and the average number of platelets increased significantly
after surgical treatment. The concentrations of D-dimer were much higher
than normal value during admission with a high variability, and
significantly decreased after surgery treatment. Further analysis found
that the changing trends of D-dimer was positively correlated with
fibrinogen protein or platelet number, but not clotting time.
Conclusions The surgical treatment method is highly effective and of
great significance for KHE therapy in pediatric clinic.