A Quantum-Chemical Approach to Develop Tetrahydroquinoxaline as Potent
Ferroptosis is a recently characterized form of regulated necrosis with
the iron-dependent accumulation of (phospho)lipid hydroperoxides (LOOH).
It has attracted considerable attention for its putative involvement in
diverse pathophysiological processes, such as cardiovascular disease and
neurodegeneration. Here we describe the discovery of
tetrahydroquinoxaline, a novel scaffold of ferroptosis inhibitors based
on quantum chemistry methods. Tetrahydroquinoxaline deviates showed very
good inhibition of ferroptosis, while being non cytotoxic for human
cancer cells. And, the advantage of them is their small molecular weight
(MW. = 148 Da) that can be coupled with other drugs to form multi-target
drugs to better meet the treatment of complicated diseases.