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Multiple breath washout quality control in the clinical setting
  • +3
  • Bettina Frauchiger,
  • Julia Carlens,
  • Andreas Herger,
  • Alexander Moeller,
  • Philipp Latzin,
  • Kathryn Ramsey
Bettina Frauchiger
Inselspital University Hospital Bern
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Julia Carlens
Medizinische Hochschule Hannover
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Andreas Herger
University Children's Hospital Zurich
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Alexander Moeller
University Children's Hospital Zurich
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Philipp Latzin
Inselspital University Hospital Bern
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Kathryn Ramsey
Inselspital University Hospital Bern
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Abstract

Background: Multiple breath washout (MBW) is increasingly used in the clinical assessment of patients with cystic fibrosis (CF). Guidelines for MBW quality control (QC) were developed primarily for retrospective assessment and central overreading. We assessed whether real-time QC of MBW data during the measurement improves test acceptability in the clinical setting. Methods: We implemented standardized real-time QC and reporting of MBW data at the time of the measurement in the clinical pediatric lung function laboratory in Bern, Switzerland in children with CF aged 4-18 years. We assessed MBW test acceptability before (31 tests; 89 trials) and after (32 tests; 97 trials) implementation of real-time QC and compared agreement between reviewers. Further, we assessed the implementation of real-time QC at a secondary center in Zurich, Switzerland. Results: Before implementation of real-time QC in Bern, only 68% of clinical MBW tests were deemed acceptable following retrospective QC by an experienced reviewer. After implementation of real-time QC, MBW test acceptability improved to 84% in Bern. In Zurich, after implementation of real-time QC, test acceptability improved from 50% to 90%. Further, the agreement between MBW operators and an experienced reviewer for test acceptability was 97% in Bern and 100% in Zurich. Conclusion: Real-time QC of MBW data at the time of measurement is feasible in the clinical setting and results in improved test acceptability.

Peer review status:UNDER REVIEW

09 Jul 2020Submitted to Pediatric Pulmonology
09 Jul 2020Submission Checks Completed
09 Jul 2020Assigned to Editor
11 Jul 2020Reviewer(s) Assigned
13 Aug 2020Review(s) Completed, Editorial Evaluation Pending
13 Aug 2020Editorial Decision: Revise Major
18 Sep 20201st Revision Received
21 Sep 2020Submission Checks Completed
21 Sep 2020Assigned to Editor
21 Sep 2020Reviewer(s) Assigned
29 Sep 2020Review(s) Completed, Editorial Evaluation Pending