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MAXIMUM EXERCISE CAPACITY, LUNG FUNCTION AND BODY COMPOSITION IN CHILDREN WITH CYSTIC FIBROSIS
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  • Gabriela Motter,
  • Marjane Cardoso,
  • Carolina Taffarel,
  • Caroline Schmidt,
  • Miriam Isabel Simon,
  • Luiz Felipe Frohlich,
  • Paulo José Marostica,
  • Paula Maria Rovedder
Gabriela Motter
Universidade Federal do Rio Grande do Sul
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Marjane Cardoso
Universidade Federal do Rio Grande do Sul
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Carolina Taffarel
Universidade Federal do Rio Grande do Sul
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Caroline Schmidt
Universidade Federal do Rio Grande do Sul
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Miriam Isabel Simon
Hospital de Clínicas de Porto Alegre
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Luiz Felipe Frohlich
UFRGS
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Paulo José Marostica
Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
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Paula Maria Rovedder
Universidade Federal do Rio Grande do Sul
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Abstract

Objective: To evaluate the oxygen uptake at peak exercise (VO2 peak) and to correlate with lung volume and capacity and body composition of children and adolescents with cystic fibrosis (CF). Methodology: Cross-sectional study with CF patients treated at the pediatric pulmonology outpatient clinic of a public hospital in Porto Alegre, aged ≥ 7 years up to 18 years. Study assessments included: cardiopulmonary stress testing, plethysmography, and body composition assessment using body bioimpedance. Results: Thirty patients were studied, with a mean peak VO2 of 1.511 ± 0.539 liters in the population studied. Correlation analysis showed a strong correlation between peak VO2 in liters and lean mass (r = 0.77 and p <0.001), and strong and inverse correlation with fat percentage (r = - 0.77 and p <0.001). ), a strong correlation with forced vital capacity (FVC) in liters (r = 0.72 and p <0.001) and forced expiratory volume in the first second (FEV1) also in liters (r = 0.69 and p <0.001). We observed a strong correlation between load (W) and lean mass and during CPET (r = 0.64 and p <0.001), and inversely with fat percentage (r = -0.64 and p <0.001). This study showed that patients with higher lean body composition have a better performance on cardiopulmonary testing, contributing to greater exercise tolerance.

Peer review status:UNDER REVIEW

10 Jul 2020Submitted to Pediatric Pulmonology
11 Jul 2020Assigned to Editor
11 Jul 2020Submission Checks Completed
16 Jul 2020Reviewer(s) Assigned
16 Aug 2020Review(s) Completed, Editorial Evaluation Pending