The Use of Tissue Sealant in Parotidectomy -- a Systematic Review and
Background: Drains are used post-parotidectomy to reduce seroma and
haematoma formation. Tissue derived thrombin sealant can enable a
drainless procedure, allowing for an earlier discharge, less discomfort
and a more cost-efficient method. We aimed to assess whether tissue
sealant improves wound-related outcomes in parotidectomy. Method: A
systematic literature review was performed using a standardised
published methodology and custom database search strategy. A
fixed-effect meta-analysis of the combined complications was conducted.
Results: Thirteen studies were identified relating to parotidectomies
using tissue sealants. Our analysis showed a statistically significant
reduction in the complication rates with tissue sealant use, including
haematoma and seroma (Odds Ratio 0.59 [0.36, 0.95], 95% CI, I2
=23%, P =0.03). Conclusion: The use of drains post-parotidectomy is
superseded by tissue sealant due to the shorter admission time and the
lower risk of post-operative complications.