Background: Drains are used post-parotidectomy to reduce seroma and haematoma formation. Tissue derived thrombin sealant can enable a drainless procedure, allowing for an earlier discharge, less discomfort and a more cost-efficient method. We aimed to assess whether tissue sealant improves wound-related outcomes in parotidectomy. Method: A systematic literature review was performed using a standardised published methodology and custom database search strategy. A fixed-effect meta-analysis of the combined complications was conducted. Results: Thirteen studies were identified relating to parotidectomies using tissue sealants. Our analysis showed a statistically significant reduction in the complication rates with tissue sealant use, including haematoma and seroma (Odds Ratio 0.59 [0.36, 0.95], 95% CI, I2 =23%, P =0.03). Conclusion: The use of drains post-parotidectomy is superseded by tissue sealant due to the shorter admission time and the lower risk of post-operative complications.