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Missing ethnic information in current BRCA variant databases
  • Zixin Qin,
  • San Ming Wang
Zixin Qin
University of Macau
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San Ming Wang
University of Macau
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Abstract

BRCA variation is highly ethnic-specific. Our analysis of major BRCA reference databases shows that nearly all databases except BIC do not provide ethnic information for their collected BRCA variants. We consider that inclusion of ethnic information of BRCA variants is necessary as it will benefit the study of human BRCA evolution, understand ethnic-basis of BRCA variation and cancer, and promote ethnic-based clinical applications in diversified ethnic populations.