Does Down Syndrome Have an Effect on Impaired Myocardial Performance in
Fetuses with Increased Nuchal Translucency?
Abstract
Objective: We aimed to evaluate myocardial performance in fetuses with
increased nuchal translucency. Method: Cases with increased NT without
any associated structural anomalies were enrolled in this study. The
study group consisted of 53 pregnancies complicated with thickened NT
> 3.5 mm. Forty-six gestational age-matched pregnant women
whose fetuses had normal NT thickness were enrolled in the study as the
control group. The TEI index was evaluated before performing CVS in the
group with an increase in NT. Karyotype analysis was performed via CVS
in all patients with increased NT. In both groups, detailed fetal
sonographic examinations, including fetal echocardiograms, were
performed between 18 and 24 weeks of gestation. Results: The differences
between normal and increased NT groups in terms of isovolumetric
relaxation time (IRT), ejection time (ET), and myocardial performance
index (MPI) variables were found to be statistically significant (p
values of 0.023, 0.004, and < 0.001, respectively). For IRT
and MPI variables, the median values of the group with an increase in NT
were found to be significantly higher than that of the normal NT group,
whereas the median value of the ET variable of the group with increased
NT was significantly lower than that of the normal NT group Conclusion:
The MPI significantly increased in the group with increased NT, but no
difference was observed between those with and without Down syndrome.
This suggests that increased NT is caused by cardiac dysfunction,
whether or not Down syndrome is present.