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Assessment of Pulmonary Arterial Stiffness in Patients with Cirrhosis: A Prospective Cohort Study
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  • Ahmet Öz,
  • Tufan Çınar,
  • Ebru Tas,
  • Suleyman Efe,
  • Burak Ayca,
  • turgut karabag
Ahmet Öz
Istanbul Egitim ve Arastirma Hastanesi
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Tufan Çınar
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Ebru Tas
Istanbul Egitim ve Arastirma Hastanesi
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Suleyman Efe
Kartal Kosuyolu Yuksek Ihtisas Heart-Education and Research Hospital
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Burak Ayca
Istanbul Egitim ve Arastirma Hastanesi
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turgut karabag
Istanbul Education and Research Hospital
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Introduction In the current literature, several studies show that pulmonary artery stiffness (PAS) is associated with right ventricular (RV) dysfunction, pulmonary arterial hypertension (PAH), and disease severity in patients with structural heart disease, human immunodeficiency virus (HIV), and chronic lung disease. Hence, in this study, we aimed to use PAS to show the early changes in the pulmonary vascular bed in patients with cirrhosis. Material and Methods In this prospective, cross-sectional study, 39 subjects who were being followed up with cirrhosis and 41 age- and sex-matched healthy participants were enrolled. For each case, the PAS value was calculated by dividing mean peak velocity of the pulmonary flow by the pulmonary flow acceleration time (PfAT). Results The measured PAS was 23.62 ± 5.87 (Hz/msn) in cirrhotic patients and 19.09 ± 4.16 (Hz/msn) in healthy subjects (p < 0.001). We found a positive statistical significance between PAS and systolic pulmonary arterial pressure (sPAP) (r = 0.378; p = 0.001). PAS was an independent predictor that was associated with cirrhosis disease according to multivariate logistic regression analysis (OR: 1.209; 95% CI: 1.059–1.381; p = 0.005). Conclusion Based on the study results, we consider that PAS may help in the early detection of changes in the pulmonary vascular bed, even if the RV function parameters or sPAP are within the normal range.

Peer review status:UNDER REVIEW

18 Jun 2020Submitted to Echocardiography
15 Jul 2020Submission Checks Completed
15 Jul 2020Assigned to Editor
16 Jul 2020Reviewer(s) Assigned
17 Aug 2020Review(s) Completed, Editorial Evaluation Pending
18 Aug 2020Editorial Decision: Revise Major
20 Aug 20201st Revision Received
21 Aug 2020Submission Checks Completed
21 Aug 2020Assigned to Editor
21 Aug 2020Reviewer(s) Assigned