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Original method of imprinting pores in scaffolds for tissue engineering
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  • Agnieszka Gadomska-Gajadhur,
  • Aleksandra Kruk,
  • Paweł Ruśkowski,
  • Paweł Sajkiewicz,
  • Judyta Dulnik,
  • Andrzej Chwojnowski
Agnieszka Gadomska-Gajadhur
Warsaw University of Technology
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Aleksandra Kruk
Warsaw University of Technology
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Paweł Ruśkowski
Warsaw University of Technology
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Paweł Sajkiewicz
Instytut Podstawowych Problemów Techniki PAN
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Judyta Dulnik
Instytut Podstawowych Problemow Techniki PAN
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Andrzej Chwojnowski
Instytut Biocybernetyki i Inzynierii Biomedycznej PAN
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Abstract

Results of the preparation of biodegradable porous scaffolds using an original modification of a wet phase inversion method were presented. Influence of gelatin nano-non-woven as a non-classic pore precursor and polyvinylpyrrolidone, Pluronic® as classic pore precursors on the structure of obtained scaffolds was analyzed. It was shown that the addition of gelatin nano-non-wovens enables the preparation of scaffolds, which allow for the growth of cells (size, distribution, and shape of pores). Mechanical properties of the obtained cell scaffolds were determined. The influence of pore precursors on mass absorption of scaffolds against isopropanol and plasma was investigated. Interaction of scaffolds with a T-lymphocyte line (Jurkat) and with fibroblasts (L929) was investigated. Obtained scaffolds are not cytotoxic and can be used as implants, e.g. the regeneration of cartilage tissue.

Peer review status:POSTED

14 Jul 2020Submitted to Biotechnology Journal
15 Jul 2020Assigned to Editor
15 Jul 2020Submission Checks Completed