Background: Most of the pregnant women with 2019 novel coronavirus pneumonia are terminated by cesarean section because the risk of mother-to-child transmission is not yet clear. The aim of this study was to evaluate maternal and perinatal outcomes of vaginal delivery of pregnant women with COVID-19 infection. Design: 8 pregnant women who were suspected or confirmed with COVID-19 infection between 31 January and 20 April,2020, gave birth vaginally in Wuhan Union hospital were included. Clinical manifestations, laboratory test results, chest CT scans and maternal and perinatal outcomes were recorded. Evidence of perinatal infection of virus was assessed by using SARS-COV-2 associated coronavirus reverse-transcriptase polymerase chain reaction in neonatal throat and anal swab samples. Results: None of the 8 pregnant women experienced dystocia and severe postpartum complications, 8 livebirths were recorded, no fetal distress or asphyxia was observed. No newborn infant had clinical COVID-19 and all investigations were negative for SARS-COV-2. Conclusions: Our study showed that vaginal delivery does not increase the probability of mother-to-child transmission of SARS-COV-2，maternal and neonatal outcomes were not affected. We suggest that pregnant women with COVID-19 pneumonia without severe systemic complications and respiratory failure can be considered for vaginal delivery.