Haploidentical Stem Cell Transplantation with Post-Transplant
Cyclophosphamide in pediatric refractory Langerhans cell histiocytosis:
a case Report
Children with multisystem - Langerhans cell histiocytosis (MS-LCH) that
fails to respond to conventional chemotherapy have poor outcomes.
Hematopoietic stem cell transplant (HSCT) represents a potential salvage
approach. We report a first case of successful haploidentical
transplantation in one child with refractory MS-LCH using T cell replete
graft and post transplant Cyclophosphamide (PT-CY) from father as a
donor. On last follow up he is 21 months post transplant with no signs
of disease activity. This case report suggests that T-cell replete
haploidentical donor transplantation using PTCY is a feasible and
successful curative option for Patients with refractory MS-LCH who have
no matched donor.