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Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide in pediatric refractory Langerhans cell histiocytosis: a case Report
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  • vipin khandelwal,
  • sanjeev sharma,
  • Dharma Choudhary,
  • divya doval,
  • SAROJ BALA,
  • anil handoo,
  • rasika setia,
  • Alka Kumar
vipin khandelwal
B L K SUPERSPECIALITY HOSPITAL
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sanjeev sharma
B L K SUPERSPECIALITY HOSPITAL
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Dharma Choudhary
BLK Superspeciality Hospital
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divya doval
BLK Superspeciality Hospital
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SAROJ BALA
B L K SUPERSPECIALITY HOSPITAL
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anil handoo
B L K SUPERSPECIALITY HOSPITAL
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rasika setia
B L K SUPERSPECIALITY HOSPITAL
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Alka Kumar
B L K SUPERSPECIALITY HOSPITAL
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Abstract

Children with multisystem - Langerhans cell histiocytosis (MS-LCH) that fails to respond to conventional chemotherapy have poor outcomes. Hematopoietic stem cell transplant (HSCT) represents a potential salvage approach. We report a first case of successful haploidentical transplantation in one child with refractory MS-LCH using T cell replete graft and post transplant Cyclophosphamide (PT-CY) from father as a donor. On last follow up he is 21 months post transplant with no signs of disease activity. This case report suggests that T-cell replete haploidentical donor transplantation using PTCY is a feasible and successful curative option for Patients with refractory MS-LCH who have no matched donor.