RELIABILITY OF ULTRASOUND-GUIDED PERCUTANEOUS CORE NEEDLE BIOPSY IN
DIAGNOSTICS OF PEDIATRIC SOLID TUMORS
Background: Ultrasound-guided percutaneous core needle biopsy (PCNB) has
been used more and more frequently in diagnostics of pediatric solid
tumors in our center. It is less invasive than an incisional biopsy.
However, reports relating to its reliability in clinical practice are
limited. Therefore, we aim to investigate the reliability of this
technique in the pediatric population. Methods: A 7-year retrospective
study including patients ≤ 18 years who underwent ultrasound-guided PCNB
in our center was conducted. Children who received PCNB and final
surgical treatment were included. Their medical records were reviewed.
Final surgical pathological diagnoses were used as the gold standard to
assess the diagnostic efficiency of PCNB. Results: A total of 169
children were included in our analysis. 87.0% of patients underwent
PCNB for abdominal and pelvic masses. 79.1% of biopsies were performed
under local anesthesia. There were 141 malignancies and 28 benign
lesions confirmed by surgery. The most common malignancy was
neuroblastoma (73), and the most common benign condition was
fibromatosis. The diagnostic yield was 94.1%. The success rate of PCNB
in determining benign and malignant conditions was 94.3% (150/159).
Consistency between PCNB and final diagnoses was found in 143 cases,
giving a total accuracy of 89.9%. The accuracy for diagnosing
malignancies was 96.8% (122/126), and for benign diseases 87.5%
(21/24). The difference was not statistically significant (p=0.0818).
Severe complications occurred in 6 patients (3.5%). No evidence of
needle tract dissemination was found. Conclusions: Ultrasound-guided
PCNB is safe and effective in diagnosing pediatric solid tumors,
especially in malignancies.