loading page

Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity
  • +6
  • Suk Won Chang,
  • Jeong Jin Park,
  • Chi Sang Hwang,
  • Jaesung Nam,
  • Jong-Gyun Ha,
  • Wasan F. Almarzouq,
  • Chang-Hoon Kim,
  • Joo-Heon Yoon,
  • Hyung-Ju Cho
Suk Won Chang
Yonsei University College of Medicine
Author Profile
Jeong Jin Park
Yonsei University College of Medicine
Author Profile
Chi Sang Hwang
Yonsei University College of Medicine
Author Profile
Jaesung Nam
Yonsei University College of Medicine
Author Profile
Jong-Gyun Ha
Yonsei University College of Medicine
Author Profile
Wasan F. Almarzouq
Yonsei University College of Medicine
Author Profile
Chang-Hoon Kim
Yonsei University College of Medicine
Author Profile
Joo-Heon Yoon
Yonsei University College of Medicine
Author Profile
Hyung-Ju Cho
Yonsei University College of Medicine
Author Profile

Abstract

Objective: To investigate the clinical significance of specific IgE-staphylococcal enterotoxin in CRS. Design: Retrospective analysis of patients who were positive for specific IgE-staphylococcal enterotoxin B. Setting: Tertiary rhinology clinic. Participants: A total of 965 patients who were positive for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017 Main outcome measures: We retrospectively reviewed the records of 965 patients who were positive for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Patient demographics, titre specific IgE to staphylococcal enterotoxin B (IgE-SEB) levels, MAST, serologic test, and medical records were reviewed. Results: IgE-SEB (KU/L) was higher in CRS patients than Non-CRS patients (0.13±0.37 vs 0.08±0.22, respectively; p-value: 0.044), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 4.46%, respectively; p-value: 0.030). IgE-SEB (KU/L) was higher in the CRS group than in the fungal sinusitis group (0.13±0.37 vs 0.03±0.05, respectively; p-value: <0.001), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 0 %, respectively; p-value: 0.015). Between the CRSsNP (chronic rhinosinusitis without nasal polyps) and CRSwNP (chronic rhinosinusitis with nasal polyps) groups, there were no differences in IgE-SEB (KU/L) or IgE-SEB (+) rates. As the values of IgE-SEB(KU/L) and the IgE-SEB (+,>0.1) rate increased, the CRS severity also increased. Conclusions: IgE-SEB showed a positive correlation with CRS severity but not with postoperative recurrence or nasal polyps. Further studies are needed to obtain clear evidence that IgE-SEB can be considered as an independent CRS endotype.

Peer review status:UNDER REVIEW

23 Jul 2020Submitted to Clinical Otolaryngology
31 Jul 2020Submission Checks Completed
31 Jul 2020Assigned to Editor
05 Aug 2020Reviewer(s) Assigned
18 Aug 2020Review(s) Completed, Editorial Evaluation Pending
23 Aug 2020Editorial Decision: Revise Major
15 Sep 20201st Revision Received
16 Sep 2020Submission Checks Completed
16 Sep 2020Assigned to Editor
20 Sep 2020Reviewer(s) Assigned