Oncofertility treatment of adult granulosa cell tumor in adolescent with
risk of thromboembolic event
Abstract
Adult granulosa cell tumor is predominant form of granulosa cell tumor,
typically diagnosed after the age of 40 years. We report a case of a
16-year-old girl with an AGCT who presented with raised testosterone
levels. After fertility sparing surgery, patient was commenced on
combined oral contraceptives (COCs) due to the menstrual cycle
irregularities. Subsequently, patient’s father developed pulmonary
embolism caused by venous thromboembolism. Hematologic evaluation in our
patient, revealed decreased protein S levels. Nevertheless, COCs were
continued for up to the six months. Since menstrual cycles
irregularities reoccurred, we are starting with progesterone-only oral
contraceptives at present time.