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Acute Kidney Injury among Salicylate Intoxication Hospitalizations in the United States
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  • Charat Thongprayoon,
  • Tananchai Petnak,
  • Wisit Kaewput,
  • Fawad Qureshi,
  • Michael Mao,
  • Aleksandra I. Pivovarova,
  • Boonphiphop Boonpheng,
  • Tarun Bathini,
  • Saraschandra Vallabhajosyula,
  • Juan Medaura,
  • Wisit Cheungpasitporn
Charat Thongprayoon
Mayo Clinic Division of Nephrology and Hypertension
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Tananchai Petnak
Mahidol University Faculty of Medicine Ramathibodi Hospital Department of Medicine
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Wisit Kaewput
Phramongkutklao College of Medicine
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Fawad Qureshi
Mayo Clinic Division of Nephrology and Hypertension
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Michael Mao
Mayo Clinic Hospital Jacksonville
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Aleksandra I. Pivovarova
University of Mississippi Medical Center
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Boonphiphop Boonpheng
University of California Los Angeles Department of Medicine
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Tarun Bathini
University of Arizona Arizona Health Sciences Center
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Saraschandra Vallabhajosyula
Emory University
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Juan Medaura
University of Mississippi Medical Center
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Wisit Cheungpasitporn
Mayo Clinic Division of Nephrology and Hypertension
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Abstract

Background: This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilization in patients hospitalized due to salicylate intoxication in the United States. Methods: Hospitalized patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End-stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clinical characteristics, in-hospital treatment, outcomes and resource utilization were compared between patients with and without AKI. Results: A total of 13,787 eligible hospital admissions were included in the analysis. AKI occurred in 1,279 (9.3%) admissions. Older age, male sex, more recent year of hospitalization, anemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis, and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in-hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay, and hospitalization cost were higher in AKI patients. Conclusion: Approximately one tenth of salicylate intoxication patients developed AKI during hospitalization. AKI was associated with higher morbidity, mortality, and resource utilizations.

Peer review status:ACCEPTED

28 Jul 2020Submitted to International Journal of Clinical Practice
30 Jul 2020Submission Checks Completed
30 Jul 2020Assigned to Editor
13 Aug 2020Reviewer(s) Assigned
28 Aug 2020Review(s) Completed, Editorial Evaluation Pending
12 Sep 20201st Revision Received
14 Sep 2020Submission Checks Completed
14 Sep 2020Assigned to Editor
14 Sep 2020Reviewer(s) Assigned
22 Sep 2020Review(s) Completed, Editorial Evaluation Pending
23 Sep 2020Editorial Decision: Accept