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Neuronal circuits on a chip for biological network monitoring
  • MIGUEL HOLGADO
MIGUEL HOLGADO
Universidad Polit├ęcnica de Madrid
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Abstract

We report a novel Cultured Neuronal Network on a chip as a viable alternative to current culture methods for the analysis of neuronal network formation and evolution of the structural properties of the network's graph . This innovative microfluidic chip fabricated from Polydimethylsiloxane, vinyl, and glass offers worthy features such as the posibility to develop and produce custom designs effortlessly, easy handling and monitoring, culture medium renewal, and reducing the exposure to contamination. Due to these benefits, longer survival of the neuronal networks are observed in comparison to conventional methods. In addition to the fast and cost-effective manufacturing of the chip, this technology provides a significant step forward in the studies of neuronal network development and many challening applications such as drug testing of in vitro cell culture models .

Peer review status:ACCEPTED

31 Jul 2020Submitted to Biotechnology Journal
04 Aug 2020Submission Checks Completed
04 Aug 2020Assigned to Editor
07 Aug 2020Reviewer(s) Assigned
15 Sep 2020Editorial Decision: Revise Major
18 Dec 20201st Revision Received
19 Dec 2020Assigned to Editor
19 Dec 2020Submission Checks Completed
19 Dec 2020Reviewer(s) Assigned
08 Mar 2021Editorial Decision: Revise Minor
16 Mar 20212nd Revision Received
17 Mar 2021Submission Checks Completed
17 Mar 2021Assigned to Editor
17 Mar 2021Reviewer(s) Assigned
28 Apr 2021Editorial Decision: Accept