loading page

Neuronal circuits on a chip for biological network monitoring
  • MIGUEL HOLGADO
MIGUEL HOLGADO
Universidad Polit├ęcnica de Madrid
Author Profile

Abstract

We report a novel Cultured Neuronal Network on a chip as a viable alternative to current culture methods for the analysis of neuronal network formation and evolution of the structural properties of the network's graph . This innovative microfluidic chip fabricated from Polydimethylsiloxane, vinyl, and glass offers worthy features such as the posibility to develop and produce custom designs effortlessly, easy handling and monitoring, culture medium renewal, and reducing the exposure to contamination. Due to these benefits, longer survival of the neuronal networks are observed in comparison to conventional methods. In addition to the fast and cost-effective manufacturing of the chip, this technology provides a significant step forward in the studies of neuronal network development and many challening applications such as drug testing of in vitro cell culture models .

Peer review status:IN REVISION

31 Jul 2020Submitted to Biotechnology Journal
04 Aug 2020Assigned to Editor
04 Aug 2020Submission Checks Completed
07 Aug 2020Reviewer(s) Assigned
15 Sep 2020Editorial Decision: Revise Major