loading page

Peanut induced anaphylaxis in children and adolescents: data from the European Anaphylaxis Registry
  • +24
  • Ioana Maris,
  • Sabine Dölle,
  • Jean-Marie Renaudin,
  • Lars Lange,
  • Alice Koehli,
  • Thomas Spindler,
  • Jonathan Hourihane,
  • Kathrin Scherer,
  • Katja Nemat,
  • C Kemen,
  • Irena Neustaedter,
  • Christian Vogelberg,
  • T. Reese,
  • Ismail Yildiz,
  • Zsolt Szepfalusi,
  • Hagen Ott,
  • Helen Straube,
  • Nikolaos Papadopoulos,
  • Susanne Haemmerling,
  • Ute Staden,
  • M. Polz,
  • Tihomir Mustakov,
  • Ewa Cichocka-Jarosz,
  • Renata Cocco,
  • Alessandro Fiocchi,
  • Montserrat Fernandez-Rivas,
  • Margitta Worm
Ioana Maris
University College Cork
Author Profile
Sabine Dölle
Charité – Universitätsmedizin Berlin
Author Profile
Jean-Marie Renaudin
University Hospital Nancy
Author Profile
Lars Lange
St. Marien-Hospital
Author Profile
Alice Koehli
University Children’s Hospital Zurich
Author Profile
Thomas Spindler
Hochgebirgsklinik Davos
Author Profile
Jonathan Hourihane
Royal College of Surgeons in Ireland Faculty of Medicine and Health Sciences
Author Profile
Kathrin Scherer
University of Basel
Author Profile
Katja Nemat
Kinderzentrum Dresden-Friedrichstadt GbR
Author Profile
C Kemen
Children's Hospital Wilhelmstift
Author Profile
Irena Neustaedter
Hospital Hallerwiese
Author Profile
Christian Vogelberg
Technical University Dresden
Author Profile
T. Reese
Mathias-Spital Rheine
Author Profile
Ismail Yildiz
Friedrich-Ebert-Hospital Neumünster
Author Profile
Zsolt Szepfalusi
Medical University of Vienna
Author Profile
Hagen Ott
Auf der Bult Children's Hospital
Author Profile
Helen Straube
Darmstädter Kinderkliniken Prinzessin Margaret
Author Profile
Nikolaos Papadopoulos
University of Manchester
Author Profile
Susanne Haemmerling
University Children's Hospital Heidelberg
Author Profile
Ute Staden
Medical practice Klettke/Staden
Author Profile
M. Polz
GPR Klinikum Russelsheim
Author Profile
Tihomir Mustakov
University Hospital Alexandrovska
Author Profile
Ewa Cichocka-Jarosz
Jagiellonian University Medical College
Author Profile
Renata Cocco
Federal University of Sao Paulo
Author Profile
Alessandro Fiocchi
Ospedale Pediatrico Bambino Gesu
Author Profile
Montserrat Fernandez-Rivas
Hospital Clinico San Carlos
Author Profile
Margitta Worm
Charité - Universitätsmedizin Berlin
Author Profile

Abstract

Background: Peanut allergy has a rising prevalence in high-income countries, affecting 0.5–1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Methods: Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food induced anaphylaxis cases in a tertiary paediatric allergy centre. Results: 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs 38%; p=0.001), asthma comorbidity (47% vs 35%; p<0.001), relevant co-factors (29% vs 22%; p=0.004) and biphasic reactions (10% vs 4%; p=0.001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs 56% and grade IV 1.1% vs 0.9%; p=0.001). Self-administration of intramuscular adrenaline was low (17% vs 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs 26%; p=0.003). Hospitalisation was higher for peanut anaphylaxis (67% vs 54%; p=0.004). Conclusions: The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g. presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.

Peer review status:IN REVISION

27 Jul 2020Submitted to Allergy
06 Aug 2020Assigned to Editor
06 Aug 2020Submission Checks Completed
06 Aug 2020Reviewer(s) Assigned
26 Aug 2020Review(s) Completed, Editorial Evaluation Pending
28 Aug 2020Editorial Decision: Revise Minor