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The predictive value of impulse oscillometry for asthma exacerbations in childhood: a systematic review and meta-analyses
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  • Yongsheng Xu,
  • Yaoyao Ling,
  • Yufan Niu,
  • Yuqi Han
Yongsheng Xu
Tianjin Children's Hospital
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Yaoyao Ling
Tianjin Medical University
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Yufan Niu
Tianjin Medical University
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Yuqi Han
Tianjin Medical University
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Background: Several studies have explored the predictive value of impulse oscillometry (IOS) for asthma exacerbations in childhood, but its specific parameters are still unclear. Therefore, we designed this meta-analysis to determine the related indicators of acute asthma attacks. Methods: A comprehensive literature search was performed in July 2020 based on Pubmed, Embase, and Web of science database. Weighted mean differences (WMD) were calculated using Fixed-or random-effects models. Results: A total of 615 patients from 6 trials were included in this analysis. IOS may be a useful tool to predict asthma exacerbations. And the results showed that R5 (WMD = − 1.21, 95%CI: −1.55 to −0.87, P<0.001), Fres (WMD = − 1.34, 95%CI: −2.03 to −0.65,P=0.018) and AX (WMD = − 7.35, 95%CI: −9.94 to −4.76,P<0.001) had significant correlation with asthma exacerbations. In addition, X5 may also predict the acute attack of asthma (WMD =0.81, 95%CI: 0.56 to 1.01, P<0.001). Conclusion: R5, AX, Fres, and X5 may be able to identify the risk of an acute attack of asthma. Besides, our research further demonstrated that peripheral airway injury may play an important role in the acute attack of asthma.

Peer review status:ACCEPTED

06 Aug 2020Submitted to Pediatric Pulmonology
06 Aug 2020Submission Checks Completed
06 Aug 2020Assigned to Editor
14 Aug 2020Reviewer(s) Assigned
26 Oct 2020Review(s) Completed, Editorial Evaluation Pending
21 Nov 2020Editorial Decision: Revise Major
08 Feb 20211st Revision Received
09 Feb 2021Submission Checks Completed
09 Feb 2021Assigned to Editor
09 Feb 2021Reviewer(s) Assigned
23 Feb 2021Review(s) Completed, Editorial Evaluation Pending
02 Mar 2021Editorial Decision: Accept