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Dimensionless Index of the Mitral Valve for Evaluation of Degenerative Mitral Stenosis
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  • Ahmet Afsin Oktay,
  • Russell Riehl,
  • Sergey Kachur,
  • Zahoor Khan,
  • Vinod Chainani,
  • Michael Cash,
  • Sangeeta Shah,
  • Carl Lavie,
  • Daniel Morin,
  • Yvonne Gilliland,
  • Salima Qamruddin
Ahmet Afsin Oktay
Ochsner Heart and Vascular Institute
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Russell Riehl
Ochsner Heart and Vascular Institute, Baylor College of Medicine
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Sergey Kachur
Ochsner Heart and Vascular Institute
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Zahoor Khan
Ochsner Heart and Vascular Institute
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Vinod Chainani
Ochsner Heart and Vascular Institute
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Michael Cash
Ochsner Medical Center
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Sangeeta Shah
Ochsner Medical Center
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Carl Lavie
Ochsner Medical Center
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Daniel Morin
Ochsner Medical Center - New Orleans
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Yvonne Gilliland
Ochsner Medical Center
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Salima Qamruddin
Ochsner Heart and Vascular Institute
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Abstract

Purpose: Degenerative mitral stenosis (DMS) is an increasingly recognized cause of mitral stenosis. The goal of this study was to compare echocardiographic differences between DMS and rheumatic mitral stenosis (RMS), identify echocardiographic variables reflective of DMS severity, and propose a dimensionless mitral stenosis index (DMSI) for assessment of DMS severity. Methods: This is a single-center, retrospective cohort study. We included patients with at least mild MS and a mean transmitral pressure gradient (TMPG) ≥ 4 mmHg. Mitral valve area by the continuity equation (MVACEQ) was used as an independent reference. The DMSI was calculated as follows: DMSI = VTILVOT / VTIMV. All-cause mortality data were collected retrospectively. Results: A total of 64 patients with DMS and 24 patients with RMS were identified. MVACEQ was larger in patients with DMS (1.43  0.4 cm2) than RMS (0.9  0.3 cm2) by ~0.5 cm2 (p = <0.001) and mean TMPG was lower in the DMS group (6.0 2 vs. 7.93 mmHg, p=0.003). A DMSI of  0.50 and ≤ 0.351 were associated with MVACEQ ≤ 1.5 and MVACEQ ≤ 1.0 cm2 (p<0.001), respectively. With the progression of DMS from severe to very severe, there was a significant drop in DMSI. There was a non-significant trend towards worse survival in patients with MVACEQ ≤ 1.0 cm2 and DMSI ≤ 0.35, suggesting severe stenosis severity. Conclusion: Our results show that TMPG correlates poorly with MVA in patients with DMS. Proposed DMSI may serve as a simple echocardiographic indicator of hemodynamically significant DMS.

Peer review status:ACCEPTED

11 Aug 2020Submitted to Echocardiography
11 Aug 2020Assigned to Editor
11 Aug 2020Submission Checks Completed
11 Aug 2020Reviewer(s) Assigned
16 Aug 2020Review(s) Completed, Editorial Evaluation Pending
17 Aug 2020Editorial Decision: Accept