Pulmonary hypertension (PH) is a severe pathophysiological condition
characterized by pulmonary artery remodeling and continuous increase in
pulmonary artery pressure, which eventually develops to right heart
failure and death. Though newly discovered and incredible treatment
strategies in recent years have improved the prognosis of PH, the fact
that limited types of effective and economical drugs for PH is available
still makes it as a life-threatening disease. Some drugs from Chinese
Materia Medica are traditionally applied in treating lung diseases.
Accumulating evidence suggests the active pharmaceutical ingredients
(APIs) derived from those medicines have brought prospective future for
prevention and treatment of PH. In this review, we summarized the
pharmacological effects of APIs derived from CMM which is potent in
treating PH, aiming at bringing new ideas in initial drug discovery and
identification of potential therapeutic strategies in alternative
medicine for PH.