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Natural ingredients from Chinese Materia Medica for Pulmonary Hypertension
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  • Jiarui Zhang,
  • Xuan Ouyang,
  • Chi Hou,
  • Wenju Lu,
  • Chunli Liu,
  • Kai Yang,
  • Nan-Shan Zhong,
  • Jian Wang,
  • Yuqin Chen
Jiarui Zhang
State Key Laboratory of Respiratory Disease
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Xuan Ouyang
State Key Laboratory of Respiratory Disease
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Chi Hou
State Key Laboratory of Respiratory Disease
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Wenju Lu
State Key Laboratory of Respiratory Disease
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Chunli Liu
State Key Laboratory of Respiratory Disease
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Kai Yang
State Key Laboratory of Respiratory Disease
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Nan-Shan Zhong
State Key Laboratory of Respiratory Disease
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Jian Wang
State Key Laboratory of Respiratory Disease
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Yuqin Chen
State Key Laboratory of Respiratory Disease
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Abstract

Pulmonary hypertension (PH) is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increase in pulmonary artery pressure, which eventually develops to right heart failure and death. Though newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH, the fact that limited types of effective and economical drugs for PH is available still makes it as a life-threatening disease. Some drugs from Chinese Materia Medica are traditionally applied in treating lung diseases. Accumulating evidence suggests the active pharmaceutical ingredients (APIs) derived from those medicines have brought prospective future for prevention and treatment of PH. In this review, we summarized the pharmacological effects of APIs derived from CMM which is potent in treating PH, aiming at bringing new ideas in initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.