Levels of Serum and Urine Catecholaminergic and Apelinergic System
Members in Acute Ischemic Stroke Patients
Abstract
Objectives: To compare levels of catecholaminergic system members,
renalase, cerebellin, and their subtrates, epinephrine, norepinephrine
and dopamine and apelinergic system members, apelin, elabela and nitric
oxide in the blood and urine of patients with acute ischemic stroke and
healthy controls. Materials and Methods: 42 patients with acute ischemic
stroke and 42 age and sex matched healthy controls were included.
Patients had first ischemic stroke attack and aged older than 18 years
old. Blood and urine samples were collected simultaneously and within
first 24 hours after the onset of acute stroke clinical manifestations
and were measured using enzyme-linked immunosorbent assay method.
Results: The levels of serum and urine cerebellin, renalase,
epinephrine, norperinephrine, dopamine, apelin, elebela and nitric oxide
were similar in ischemic stroke and in control groups (P>
0.05). Strong correlations were found between renalase, cerebellin and
catecholamine levels in serum and urine (p <0.001) both in
stroke patients and controls. There were also strong correlations
between apelin, elabela and NO levels in serum and urine (p
<0.001) in two groups. Conclusions: Serum and urine
cerebellin, renalase, epinephrine, norperinephrine, dopamine, apelin,
elebela and nitric oxide levels do not significantly change in the acute
phase of ischemic stroke. Strong correlations among renalase, cerebellin
and catecholamines emphasize that these substances act together in
healthy individuals and ischemic stroke patients. Similarly, strong
correlations between apelin, elabela and NO indicate that these agents
act together in healthy subjects and patients with ischemic stroke.