loading page

The origin of island populations of the African malaria mosquito, Anopheles coluzzii
  • +6
  • Melina Campos,
  • Mark Hanemaaijer,
  • Hans Gripkey,
  • Travis Collier,
  • Yoosook Lee,
  • Anthoney Cornel,
  • Joao Pinto,
  • Herodes Rompão,
  • Gregory Lanzaro
Melina Campos
University of California Davis
Author Profile
Mark Hanemaaijer
University of California Davis
Author Profile
Hans Gripkey
University of California Davis
Author Profile
Travis Collier
University of California Davis
Author Profile
Yoosook Lee
University of California Davis
Author Profile
Anthoney Cornel
University of California Davis
Author Profile
Joao Pinto
Universidade Nova de Lisboa
Author Profile
Herodes Rompão
Programa Nacional de Luta Contra o Paludismo
Author Profile
Gregory Lanzaro
University of California Davis
Author Profile

Abstract

Anopheles coluzzii is a major malaria vector throughout its distribution in west-central Africa. Here we present a whole-genome resequencing study of 77 specimens from eight localities, that covers a large part of this species’ range, including three islands in the Gulf of Guinea: Bioko, São Tomé and Príncipe. Population genomic analyses encompassed structure of mainland populations, of island populations and connectivity between island and mainland populations. Three genetic clusters were found among mainland populations and genetic distances among all populations fit an isolation-by-distance model. Genomic analyses were applied to estimating the demographic history and ancestry (cross-coalescence) for each island. Taken together with the unique biogeography and history of human occupation for each island they present a coherent explanation underlying contemporary levels of genetic isolation between mainland and island populations and among island populations. We discuss the relation of our findings to the suitability of São Tomé and Príncipe islands as candidate sites for potential field trials of genetic-based malaria control strategies.

Peer review status:UNDER REVIEW

20 Aug 2020Submitted to Molecular Ecology
21 Aug 2020Assigned to Editor
21 Aug 2020Submission Checks Completed
05 Sep 2020Reviewer(s) Assigned