loading page

Colistin-Resistant Enterobacter kobei carrying mcr-9.1 and blaCTX-M-15 infecting a critically endangered Franciscana dolphin (Pontoporia blainvillei), Brazil
  • +7
  • Danny Fuentes-Castillo,
  • Fábio Sellera,
  • Daphne Goldberg,
  • Herrison Fontana,
  • Fernanda Esposito,
  • Brenda Cardoso,
  • Joanna Ikeda,
  • Anneliese Kyllar,
  • José Luiz Catão-Dias,
  • Nilton Lincopan
Danny Fuentes-Castillo
University of Sao Paulo, University of São Paulo
Author Profile
Fábio Sellera
University of Sao Paulo
Author Profile
Daphne Goldberg
Londrina State University
Author Profile
Herrison Fontana
University of Sao Paulo
Author Profile
Fernanda Esposito
School of Pharmaceutical Sciences, University of São Paulo
Author Profile
Brenda Cardoso
Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo
Author Profile
Joanna Ikeda
Author Profile
Anneliese Kyllar
UERJ
Author Profile
José Luiz Catão-Dias
Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo
Author Profile
Nilton Lincopan
University of São Paulo
Author Profile

Abstract

The emergence of mobile mcr genes mediating resistance to colistin is a critical public health issue that has hindered the treatment of serious infections caused by multidrug-resistant pathogens in humans and other animals. We report the emergence of the mcr-9.1 gene in a polymyxin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacter kobei infecting a free-living Franciscana dolphin (Pontoporia blainvillei), threatened with extinction in South America. Genomic analysis confirmed a wide resistome with additional presence of genes conferring resistance to clinically relevant β-lactam [blaCTX-M-15, blaACT-9, blaOXA-1 and blaTEM-1B], aminoglycoside [aac(3)-IIa, aadA1, aph(3’‘)-Ib and aph(6)-Id], trimethoprim [dfrA14], tetracycline [tetA], quinolone [aac(6’)-Ib-cr and qnrB1], fosfomycin [fosA], sulphonamide [sul2], and phenicol [catA1 and catB3] antibiotics. The identification of mcr-9.1 in a CTX-M-15-producing pathogen infecting a critically endangered animal is worryingly, due to the restricted therapeutic options, and should be interpreted as a sign of further spread of critical-priority pathogens and their resistance genes in threatened ecosystems.

Peer review status:UNDER REVIEW

22 Aug 2020Submitted to Transboundary and Emerging Diseases
22 Aug 2020Assigned to Editor
22 Aug 2020Submission Checks Completed
26 Aug 2020Reviewer(s) Assigned