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Advances and Recent Developments in Asthma in 2020
  • +19
  • Lacin Cevhertas,
  • Ismail Ogulur,
  • debbie maurer,
  • daniel burla,
  • Mei Ding,
  • Kirstin Jansen,
  • Jana Koch,
  • Chengyao Liu,
  • Siyuan Ma,
  • yasutaka mitamura,
  • Yaqi Peng,
  • Urszula Radzikowska,
  • Arturo Rinaldi,
  • Pattraporn Satitsuksanoa,
  • anna globinska,
  • Willem van de Veen,
  • Milena Sokolowska,
  • Katja Baerenfaller,
  • Ya-dong Gao,
  • Ioana Agache,
  • Mubeccel Akdis,
  • Cezmi Akdis
Lacin Cevhertas
University of Zurich Swiss Institute of Allergy & Asthma Research
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Ismail Ogulur
Marmara Universitesi
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debbie maurer
Swiss Institute of Allergy and Asthma Research, University of Zurich
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daniel burla
University of Zurich Swiss Institute of Allergy & Asthma Research
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Mei Ding
Swiss Institute of Allergy and Asthma Research
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Kirstin Jansen
University of Zurich
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Jana Koch
University of Zurich Swiss Institute of Allergy & Asthma Research
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Chengyao Liu
University of Zurich Swiss Institute of Allergy & Asthma Research
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Siyuan Ma
University of Zurich Swiss Institute of Allergy & Asthma Research
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yasutaka mitamura
University of Zurich Swiss Institute of Allergy & Asthma Research
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Yaqi Peng
Swiss Institute of Allergy and Asthma Research
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Urszula Radzikowska
Swiss Institute of Allergy and Asthma Research
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Arturo Rinaldi
Swiss Institute for Allergy and Asthma Research (SIAF)
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Pattraporn Satitsuksanoa
SIAF
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anna globinska
University of Zurich Swiss Institute of Allergy & Asthma Research
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Willem van de Veen
University of Zurich
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Milena Sokolowska
Swiss Institute of Allergy and Asthma Research, University of Zurich
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Katja Baerenfaller
Swiss Institute of Allergy and Asthma Research
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Ya-dong Gao
Zhongnan Hospital of Wuhan University
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Ioana Agache
Transylvania University of Brasov
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Mubeccel Akdis
University of Z├╝rich
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Cezmi Akdis
University of Zurich
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Abstract

In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2 and Covid-19.

Peer review status:ACCEPTED

21 Aug 2020Submitted to Allergy
24 Aug 2020Submission Checks Completed
24 Aug 2020Assigned to Editor
25 Aug 2020Reviewer(s) Assigned
09 Sep 2020Review(s) Completed, Editorial Evaluation Pending
09 Sep 2020Editorial Decision: Revise Minor
23 Sep 20201st Revision Received
23 Sep 2020Submission Checks Completed
23 Sep 2020Assigned to Editor
24 Sep 2020Review(s) Completed, Editorial Evaluation Pending
24 Sep 2020Editorial Decision: Accept