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The Effect of Body Mass Index on Oncological and Surgical Outcomes in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Multicenter Study of the Association of Urooncology, Turkey
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  • Volkan Izol,
  • Mutlu Deger,
  • Sumer Baltacı,
  • Murat Akgul,
  • İsmail Selvi,
  • Ender Ozden,
  • Evren Suer,
  • Mustafa Tansug
Volkan Izol
Cukurova University Faculty of Medicine
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Mutlu Deger
Cukurova University Faculty of Medicine
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Sumer Baltacı
Ankara University Faculty of Medicine
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Murat Akgul
Namik Kemal University Faculty of Medicine
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İsmail Selvi
Ankara Kecioren Training and Research Hospital
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Ender Ozden
Ondokuz Mayis University Faculty of Medicine
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Evren Suer
Ankara University Faculty of Medicine
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Mustafa Tansug
Cukurova University Faculty of Medicine
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Abstract

Objective: We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). Materials and Methods We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for BC recorded in the bladder cancer database of the Urooncology Association, Turkey between 2007 and 2019. Patients were stratified into three groups according to the BMI cut-off values recommended by the WHO; Group 1 (normal weight, <25 kg/m2), Group 2 (overweight, 25.0–29.9 kg/m2) and Group 3 (obese, ≥30 kg/m2) Results In all, 494 patients were included, of them 429 (86.8%) were male and 65 (13.2%) were female. The median follow-up was 24 months (12-132 months). At the time of surgery, the number of patients in groups 1, 2 and 3 were 202 (40.9%), 215 (43.5%) and 77 (15.6%), respectively. The mean operation time and time to postoperative oral feeding were longer and major complications were statistically higher in Group 3 compared to Groups 1 and 2 (p=0.019, p<0.001 and p=0.025 respectively). Although the mean overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS) and metastasis-free survival (MFS) was shorter in cases with BMI ≥30 kg/m2 compared with other BMI groups, differences were not statistically significant (p=0.532, p=0.309, p=0.751 and p=0.213 respectively). Conclusion Our study showed that, although major complications are more common in obese patients, the increase in BMI does not reveal a significant negative effect on OS, CSS, RFS, and MFS.

Peer review status:ACCEPTED

24 Aug 2020Submitted to International Journal of Clinical Practice
24 Aug 2020Submission Checks Completed
24 Aug 2020Assigned to Editor
31 Aug 2020Reviewer(s) Assigned
04 Sep 2020Review(s) Completed, Editorial Evaluation Pending
11 Sep 20201st Revision Received
11 Sep 2020Submission Checks Completed
11 Sep 2020Assigned to Editor
11 Sep 2020Reviewer(s) Assigned
13 Sep 2020Review(s) Completed, Editorial Evaluation Pending
23 Sep 2020Editorial Decision: Accept