loading page

Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama
  • +14
  • Fermin Acosta,
  • Anders Norman,
  • Dilcia Sambrano,
  • Victoria Batista,
  • Igor Mokrousov,
  • Egor Shitikov,
  • Julio Jurado,
  • Maritza Mayrena,
  • Odemaris Luque,
  • Maybis Garay,
  • Laura Solis,
  • Patricia Muñoz,
  • Dorte Bek Folkvardsen,
  • Troels Lillebaek,
  • laura Pérez-Lago,
  • Amador Goodridge,
  • Darío García de Viedma
Fermin Acosta
Hospital General Universitario Gregorio Marañón
Author Profile
Anders Norman
International Reference Laboratory of Mycobacteriology
Author Profile
Dilcia Sambrano
INDICASAT
Author Profile
Victoria Batista
INDICASAT
Author Profile
Igor Mokrousov
St. Petersburg Pasteur Institute
Author Profile
Egor Shitikov
Federal Research and Clinical Center of Physical-Chemical Medicine
Author Profile
Julio Jurado
Caja de Seguro Social
Author Profile
Maritza Mayrena
Caja de Seguro Social
Author Profile
Odemaris Luque
Programa de Control de Tuberculosis, Ministerio de Salud
Author Profile
Maybis Garay
INDICASAT
Author Profile
Laura Solis
Programa de Control de Tuberculosis, Ministerio de Salud
Author Profile
Patricia Muñoz
Hospital General Universitario Gregorio Marañón
Author Profile
Dorte Bek Folkvardsen
International Reference Laboratory of Mycobacteriology
Author Profile
Troels Lillebaek
International Reference Laboratory of Mycobacteriology
Author Profile
laura Pérez-Lago
Hospital General Universitario Gregorio Marañón
Author Profile
Amador Goodridge
INDICASAT
Author Profile
Darío García de Viedma
Author Profile

Abstract

Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance, and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidence of tuberculosis in the country. Retrospective Mycobacterial Interspersed Repetitive-Unit/Variable-Number of Tandem Repeats analysis of 42 isolates collected between January-August 2018, allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain-specific PCR based surveillance from September 2019 to March 2020, confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole genome sequencing revealed higher-than-expected diversity within the cluster, suggesting long-term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012.

Peer review status:UNDER REVIEW

24 Aug 2020Submitted to Transboundary and Emerging Diseases
25 Aug 2020Submission Checks Completed
25 Aug 2020Assigned to Editor
26 Aug 2020Reviewer(s) Assigned
18 Sep 2020Review(s) Completed, Editorial Evaluation Pending
19 Sep 2020Editorial Decision: Revise Minor
24 Sep 20201st Revision Received
25 Sep 2020Submission Checks Completed
25 Sep 2020Assigned to Editor
25 Sep 2020Reviewer(s) Assigned