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Cardiogenic shock on 5-fluoruracile: a rare, fulminant and transient disease that deserves attention
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  • Tiphaine Lambert,
  • Valérie Boige,
  • Patrick Bruneval,
  • Agnès Lillo-Lelouet,
  • Daniel Orbach,
  • Mariana Mirabel
Tiphaine Lambert
Institut Curie
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Valérie Boige
Insitut Gustave Roussy, Villejuif, France
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Patrick Bruneval
Assistance Publique - Hopitaux de Paris
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Agnès Lillo-Lelouet
Assistance Publique - Hopitaux de Paris
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Daniel Orbach
Institut Curie
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Mariana Mirabel
Assistance Publique - Hopitaux de Paris
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Abstract

Five-fluorouracil (5-FU) and platins remain a first line treatment in oncology with a potential of cardiovascular toxicity. We identified two cases of acute severe cardiac toxicity treated with a combination of 5FU (different production batch) and platins at three months interval at two different institutions referred to our cardio-oncology services. Both cases had similar clinical presentation, favorable outcomes and identical cardiac magnetic imaging scans at follow-up. Mechanism was direct myocardial toxicity in the case with endomyocardial biopsy. Circulatory support as a bridge to recovery should be considered in the case of untreatable cardiogenic shock likely due to 5-FU.