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Relationship between bronchopulmonary dysplasia phenotypes and clinical outcomes with HRCT score in preterm infants
  • Qiong Yao,
  • Li-li He,
  • Xi-hong Hu
Qiong Yao
Children's Hospital of Fudan University
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Li-li He
Children's Hospital of Fudan University
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Xi-hong Hu
Children's Hospital of Fudan University
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Abstract

Background: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities with the clinical phenotypes and outcomes in preterm bronchopulmonary dysplasia (BPD) infants. Methods: Totally, 81 preterm infants were enrolled between 2013 and 2020. Clinical phenotypes of BPD mainly include BPD severity, pulmonary hypertension (PH), and large airway lesion (LAL). The outcomes included death before hospital discharge, home oxygen treatment, or home pulmonary vasodilator therapy, were assessed. Total scores (TS) of high-resolution CT (HRCT) were summed in every lobe in 7 aspects: hyperaeration score (HS), composing decreased attenuation, mosaic attenuation, and bulla/bleb; parenchyma score (PS), composing linear lesions, consolidation, bronchial wall thickening, and bronchiectasis. Results: TS (r=0.49), HS (r=0.31), PS (r=0.30), decreased attenuation (r=0.21), mosaic attenuation (r=0.31), bulla/Bleb (r=0.27) and linear densities (r=0.55) displayed a correlation with BPD severity. TS (r=0.28), PS (r=0.35), linear densities (r=0.34) and consolidation (r=0.24) displayed a correlation with PH. TS (OR 1.11, 95% CI 1.01-1.21), PS (OR 1.17, 95% CI 1.01-1.36) and linear densities (OR 2.23, 95% CI 1.34-3.71) was related to the composite outcomes. Linear densities (OR 2.30, 95% CI 0.96-5.49), TS (OR 1.16, 95% CI 1.01-1.33) and HS (OR 1.17, 95% CI 1.01-1.35) was associated with pulmonary vasodilator. Consolidation (OR 2.09, 95% CI 1.07-4.08) and PS (OR 1.27, 95% CI 1.00-1.60) was closely related to the death. Linear densities (OR 2.36, 95% CI 1.22-4.57, p=0.01) were risk factors of home oxygen therapy. Conclusions: HRCT scores were correlated with the BPD severity, PH and poor clinical outcome.