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Past hormonal contraceptive use and pre-eclampsia among pregnant women in Northwest Ethiopia: a case- control study
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  • Abiyot Asres,
  • Abigiya Tilahun,
  • Sisay Waji,
  • Getachew Adella,
  • Adamu Addissie
Abiyot Asres
Wolaita Sodo University
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Abigiya Tilahun
Addis Ababa University
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Sisay Waji
Addis Ababa University
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Getachew Adella
Wolaita Sodo University
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Adamu Addissie
Addis Ababa University
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Abstract

Objective To determine the association between past hormonal contraceptive use and preeclampsia among pregnant women in public hospitals. Design A case-control study was conducted in the selected public hospitals in Northwest Ethiopia. Setting Public hospitals in Northwest Ethiopia. Sample One hundred ten cases and two hundred twenty controls were selected consecutively in the selected public hospitals. Women who had preeclampsia during diagnosis were considered as cases and women with the absence of preeclampsia were controls. Methods The data was obtained through reviewing women’s record, taking measurements and face to face interview using structured interviewer administrator questionnaire. Then the data was entered into EPI info and transferred to STATA version 14 for statistical analysis. Frequency distributions, percentages and multivariate logistic regression were done to assess the association between past hormonal contraceptive use and preeclampsia. Main outcome measures Odds ratios with 95% confidence intervals of pre-eclampsia in pregnancies among women with a history of hormonal contraceptive use, compared with women without a history of hormonal contraceptive use. Results There was no significant association between past hormonal contraceptive use prior to current pregnancy and preeclampsia except implant. Women who used before current pregnancy were less likely to develop preeclampsia (AOR=0.39, 95%CI: (0.13-0.96)). No association was observed between preeclampsia and other hormonal contraceptives (pills, injectables and intrauterine contraceptive devices). Conclusions This stud revealed that there was no significant association between past hormonal contraceptive use and preeclampsia except implant which was negatively associated with preeclampsia. Key words Hormonal contraceptive use, preeclampsia, pregnancy