Past hormonal contraceptive use and pre-eclampsia among pregnant women
in Northwest Ethiopia: a case- control study
Abstract
Objective To determine the association between past hormonal
contraceptive use and preeclampsia among pregnant women in public
hospitals. Design A case-control study was conducted in the selected
public hospitals in Northwest Ethiopia. Setting Public hospitals in
Northwest Ethiopia. Sample One hundred ten cases and two hundred twenty
controls were selected consecutively in the selected public hospitals.
Women who had preeclampsia during diagnosis were considered as cases and
women with the absence of preeclampsia were controls. Methods The data
was obtained through reviewing women’s record, taking measurements and
face to face interview using structured interviewer administrator
questionnaire. Then the data was entered into EPI info and transferred
to STATA version 14 for statistical analysis. Frequency distributions,
percentages and multivariate logistic regression were done to assess the
association between past hormonal contraceptive use and preeclampsia.
Main outcome measures Odds ratios with 95% confidence intervals of
pre-eclampsia in pregnancies among women with a history of hormonal
contraceptive use, compared with women without a history of hormonal
contraceptive use. Results There was no significant association between
past hormonal contraceptive use prior to current pregnancy and
preeclampsia except implant. Women who used before current pregnancy
were less likely to develop preeclampsia (AOR=0.39, 95%CI:
(0.13-0.96)). No association was observed between preeclampsia and other
hormonal contraceptives (pills, injectables and intrauterine
contraceptive devices). Conclusions This stud revealed that there was no
significant association between past hormonal contraceptive use and
preeclampsia except implant which was negatively associated with
preeclampsia. Key words Hormonal contraceptive use, preeclampsia,
pregnancy