The new coronavirus has been named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible of the COVID-19 illness, it is a virus that belongs to the Coronavirus family, it is the third virus in this family that causes an epidemic. It originated in China and has spread throughout the world. It is highly pathogenic and transmissible that mainly affects the respiratory tract and can cause death. There is not antiviral drug or vaccines against COVID-19 illness, infected person only have supportive treatments. Recently, some antiviral drugs and vaccines are being valued. In this review, we described the general characteristics of HCoVs and latest research of the transmission, prevention and clinical characteristics of SARS-CoV-2 and some treatments and vaccines more development for to combat COVID-19 illness.