Assessment of antidiabetic potential of Berberis lycium Royle root bark
extract in experimental animal model
Abstract
Background: Various medicines are in practice for the treatment of
diabetes mellitus but phyto-based medicines got paramount importance in
this regard. The current investigation focused on inspection of
antidiabetic potential of Berberis lycium Royle root bark extract.
Methods: α-amylase and α-glucosidase inhibition assay were performed for
the evaluation of in-vitro antidiabetic activity. In-vivo antidiabetic
potential was estimated in alloxan-induced swiss albino mice. Diabetic
mice were treated with aqueous root bark extract (200 mg/kg b.w.) for 28
days. At the end of 28 days treatment period mice were sacrificed for
biochemical and histopathological analysis of pancreas, liver and
kidney. Results: Blood glucose level and all other biochemical
parameters were significantly normalized when treated with B. lycium
Royle root bark extract. Results of both in-vitro and in-vivo activity
showed that B. lycium Royle has antidiabetic effect. Conclusion: B.
lycium Royle root bark extract presented efficient antidiabetic activity
in the diabetic mice model and therefore could have potential for
development of drugs in the future. Keywords: Diabetes, alloxan,
medicinal plants, Berberis lycium Royle