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Cannabinoid Receptor and Inflammation
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  • Newman Osafo,
  • Oduro Yeboah,
  • Aaron Antwi,
  • George Ainooson
Newman Osafo
Kwame Nkrumah University of Science and Technology
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Oduro Yeboah
Kwame Nkrumah University of Science and Technology
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Aaron Antwi
Kwame Nkrumah University of Science and Technology
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George Ainooson
Kwame Nkrumah University of Science and Technology
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Abstract

The eventual discovery of endogenous cannabinoid receptors CB1 and CB2 and their endogenous ligands has generated interest with regards to finally understanding the endocannabinoid system. Its role in the normal physiology of the body and its implication in pathological states such as cardiovascular diseases, neoplasm, depression and pain have been subjects of scientific interest. In this review the authors focus on the endogenous cannabinoid pathway, the critical role of cannabinoid receptors in signaling and mediation of neurodegeneration and other inflammatory responses as well as its potential as a drug target in the amelioration of some inflammatory conditions. Though the exact role of the endocannabinoid system is not fully understood, the evidence found leans heavily towards a great potential in exploiting both its central and peripheral pathways in disease management. Cannabinoid therapy has already shown great promise in several preclinical and clinical trials.