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Bone marrow necrosis in pediatric malignancies - 10-year retrospective review and review of literature
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  • Michell Lozano-Chinga,
  • Lauren Draper,
  • Tracy George,
  • Archana Agarwal,
  • David Dansie,
  • Luke Maese
Michell Lozano-Chinga
Primary Children's Hospital
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Lauren Draper
Saint Louis University
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Tracy George
The University of Utah School of Medicine
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Archana Agarwal
University of Utah
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David Dansie
Primary Children's Hospital
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Luke Maese
University of Utah School of Medicine
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Abstract

Bone marrow necrosis (BMN) is a rare pathologic finding, but when encountered is most often associated with malignancy. In adults its presence correlates with an inferior prognosis, however in children the prognostic implication is unclear. We performed a retrospective review of 3,760 bone marrow specimens in patients ≤ 18 years over a ten-year period. BMN was identified in less than 1% of specimens and only in patients with leukemia, lymphoma or neuroblastoma. BMN contributed to a delay in diagnosis; however, advanced medical imaging may serve as a tool to localize non-necrotic areas for bone marrow sampling, facilitating an expedited diagnosis.

Peer review status:UNDER REVIEW

08 Sep 2020Assigned to Editor
08 Sep 2020Submission Checks Completed
08 Sep 2020Submitted to Pediatric Blood & Cancer
10 Sep 2020Reviewer(s) Assigned