Since the 1980’s the field of process control has become increasingly important in chemical and petrochemical plants, oil refineries and other manufacturing units. They are widely used are & still a very powerful tool in process control domain is the PID controller. To get optimal performance of any PID controller and to extract the full economic and safety benefits of it, appropriate PID tuning is required. This paper examines and compares industrial mostly-used old-fashion PID controller tuning method with the better PITOPS simulator. Old-fashion PID controller tuning method use Trail-and-Error approach or Empirical sets of rules, whereas the PITOPS technology uses powerful mathematical NC-GRG (Nonlinear Constrained General Reduced Gradient) optimization approach developed by International automation and process control company PiControl Solutions. The main goal of the paper is to highlight the benefits of PITOPS over the mostly-used old-fashion methods for industrial PID controller tuning, over several typical examples.