Effect of Orlistat on serum Uric acid level in adults: A systematic
review and meta-analysis of randomized controlled trials
Objective: Hyperuricemia increases the risk of gout and cardiovascular
diseases. Obesity increase the risk of hyperuricemia while weight loss
(>5 kg) has been reported to decrease urate. The effects of
orlistat on serum uric acid is still controversial. The aim of this
meta-analysis was to evaluate the influence of orlistat on serum uric
acid level in adults. Methods: Relevant studies, published up to May
2020, were searched systematically through PubMed/Medline, Scopus, and
Google Scholar. All relevant randomized controlled clinical trials were
included. Meta-analysis was performed using random-effect model.
Subgroup analysis, sensitivity analysis, and meta-regression were also
carried out Results: Overall 7 trials (9 dataset) that enrolled 1786
subjects were included. Orlistat showed in significant change in serum
uric acid level (Difference in means: -17.661μmol, 95% CI: -31.615 to
-3.707, P=0.01). A low heterogeneity observed across the studies (I^2
= 25.119%). After categorizing studies on the basis of duration and
sample size the effect of orlistat on serum uric acid was significant.
The results of meta-regression were showed that significant
relationships were not found between orlistat and serum uric acid in
duration of intervention. Conclusion: We found a significant reduction
in serum uric acid following orlistat therapy in adults.