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Left Ventricular Longitudinal Myocardial Contraction Is Associated with Cognitive Status: A Cross-Sectional Study in Community-Dwelling Populations
  • +14
  • liu yongtai,
  • lai jinzhi,
  • zhai feifei,
  • han fei,
  • zhou lixin,
  • ni jun,
  • yao ming,
  • Zhuang Tian,
  • zhu yanlin,
  • chen wei,
  • bai hua,
  • wang hui,
  • zhang dingding,
  • cui liying,
  • jin zhengyu,
  • zhang shuyang,
  • zhu yicheng
liu yongtai
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lai jinzhi
Peking Union Medical College Hospital
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zhai feifei
Peking Union Medical College Hospital
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han fei
Peking Union Medical College Hospital
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zhou lixin
Peking Union Medical College Hospital
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ni jun
Peking Union Medical College Hospital
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yao ming
Peking Union Medical College Hospital
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Zhuang Tian
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
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zhu yanlin
Peking Union Medical College Hospital
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chen wei
Peking Union Medical College Hospital
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bai hua
Peking Union Medical College Hospital
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wang hui
Peking Union Medical College Hospital
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zhang dingding
Peking Union Medical College Hospital
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cui liying
Peking Union Medical College Hospital
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jin zhengyu
Peking Union Medical College Hospital
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zhang shuyang
Peking Union Medical College Hospital
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zhu yicheng
Peking Union Medical College Hospital
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Abstract

Aims: The interaction between the heart and brain is highly complex. Left ventricular (LV) longitudinal contraction is the most sensitive to the presence of myocardial disease. Whether subclinical change in LV longitudinal contraction assessed by echocardiography is associated with cognitive impairment in the general population has not been investigated. Methods and Results: All residents aged ≥ 35 years, living in five villages of Shunyi, a suburb district of Beijing, were invited to participate in the study from June 2013 to April 2016. This was an exploratory cross-sectional analysis of the baseline data of 894 participants enrolled in the Shunyi Study. Cognitive status was evaluated using the Montreal Cognitive Assessment (MoCA). LV longitudinal contraction was assessed by the peak systolic velocity measured at the mitral annulus (Sm) obtained by Tissue Doppler imaging echocardiography. Cognitive impairment (MoCA score <26) was found in 771 (86.2%) participants. LV longitudinal myocardial contraction (Sm) and diastolic function (Em, E/A ratio, and E/e) were associated with cognitive impairment (all P<0.01). The association between Sm and cognitive impairment remained significant after adjusting for age, sex, education level, physical activity, vascular risk factors, and cerebral small-vessel disease (OR, 0.84; 95% CI, 0.73–0.97, P=0.02). Receiver operating characteristic curve analysis for Sm in identifying normal cognitive status showed the area under the curve of 0.59 (95% CI, 0.54–0.65; P<0.01). Conclusions: Our findings suggest that LV longitudinal myocardial contraction in the general population is associated with cognitive status in Chinese community-dwelling populations.