Left Ventricular Longitudinal Myocardial Contraction Is Associated with
Cognitive Status: A Cross-Sectional Study in Community-Dwelling
Populations
Abstract
Aims: The interaction between the heart and brain is highly complex.
Left ventricular (LV) longitudinal contraction is the most sensitive to
the presence of myocardial disease. Whether subclinical change in LV
longitudinal contraction assessed by echocardiography is associated with
cognitive impairment in the general population has not been
investigated. Methods and Results: All residents aged ≥ 35 years, living
in five villages of Shunyi, a suburb district of Beijing, were invited
to participate in the study from June 2013 to April 2016. This was an
exploratory cross-sectional analysis of the baseline data of 894
participants enrolled in the Shunyi Study. Cognitive status was
evaluated using the Montreal Cognitive Assessment (MoCA). LV
longitudinal contraction was assessed by the peak systolic velocity
measured at the mitral annulus (Sm) obtained by Tissue Doppler imaging
echocardiography. Cognitive impairment (MoCA score <26) was
found in 771 (86.2%) participants. LV longitudinal myocardial
contraction (Sm) and diastolic function (Em, E/A ratio, and E/e) were
associated with cognitive impairment (all P<0.01). The
association between Sm and cognitive impairment remained significant
after adjusting for age, sex, education level, physical activity,
vascular risk factors, and cerebral small-vessel disease (OR, 0.84; 95%
CI, 0.73–0.97, P=0.02). Receiver operating characteristic curve
analysis for Sm in identifying normal cognitive status showed the area
under the curve of 0.59 (95% CI, 0.54–0.65; P<0.01).
Conclusions: Our findings suggest that LV longitudinal myocardial
contraction in the general population is associated with cognitive
status in Chinese community-dwelling populations.