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Evaluation of Regular Insulin Adsorption to Polypropylene Bag and Polyvinyl Chloride Infusion Set
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  • Nursel Sürmelioğlu,
  • Merve Nenni,
  • Ahmet Fırat,
  • Kutay Demirkan,
  • Dilek Özcengiz
Nursel Sürmelioğlu
Cukurova University
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Merve Nenni
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Ahmet Fırat
Faculty of Medicine, Çukurova University
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Kutay Demirkan
Hacettepe University Faculty of Pharmacy
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Dilek Özcengiz
Faculty of Medicine, Çukurova University
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Abstract

Aim Clinical application of insulin infusion therapy is usually accomplished with regular human insulin. It is known that the regular insulin adsorbed to the hydrophobic surfaces and different approaches were implemented into the clinical practices. It was aimed to evaluate the rate of adsorption of insulin to PP bags and PVC infusion sets and stability of insulin during the infusion. Methods 100 IU insulin was added to PP bags containing 100 ml of 0.9% NaCl solution(n = 6). The infusion was started at a rate of 2 ml/h using infusion sets in the PVC structure. Insulin quantification was performed in the samples taken both from the bag and from the end tip of the infusion set during infusion. The stability of insulin solutions stored at room (+24°C) and refrigerator (+4°C) temperatures were compared. Samples were analyzed using reverse-phase high-performance liquid chromatography. Results No statistically significant difference was found between the concentrations of the samples taken from the bags stored at room and refrigerator temperatures at the 4th, 12th, and 24th hours (p>0.05). It was seen that the adsorption rate of insulin to PVC set was 57% and PP bags is at most 5% at the 24th hour. Conclusion When PP bags are used for insulin infusion, it is predicted that 24-hour change can be made instead of frequent change. In addition, losses caused by the high rate of insulin adsorption to PVC infusion sets should be considered and PP infusion sets would be the better option to use if available.

Peer review status:ACCEPTED

21 Sep 2020Submitted to International Journal of Clinical Practice
21 Sep 2020Submission Checks Completed
21 Sep 2020Assigned to Editor
25 Sep 2020Reviewer(s) Assigned
20 Oct 2020Review(s) Completed, Editorial Evaluation Pending
27 Oct 20201st Revision Received
28 Oct 2020Submission Checks Completed
28 Oct 2020Assigned to Editor
28 Oct 2020Reviewer(s) Assigned
12 Nov 2020Review(s) Completed, Editorial Evaluation Pending
01 Dec 2020Editorial Decision: Accept