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The Role of POPDC1 in the Progression of the Malignant Phenotype
  • Steve Tucker,
  • Alina Zorn
Steve Tucker
University of Aberdeen
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Alina Zorn
University of Aberdeen
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Abstract

The Popeye Domain Containing Protein 1 (POPDC1), a tight junction-associated transmembrane protein with a unique binding site for cAMP, has been shown to act as a tumour suppressor in cancer cells. Through interaction with many downstream effectors and signalling pathways, POPDC1 promotes cell adhesion and inhibits uncontrolled cell proliferation, epithelial-to-mesenchymal transition, and metastasis. However, POPDC1 expression is downregulated in many types of cancer, thereby reducing its tumour-suppressive actions. This review discusses the role of POPDC1 in the progression of the malignant phenotype and highlights the broad range of benefits POPDC1 stabilisation may achieve therapeutically. Cancer stem cells (CSC) are a key hallmark of malignancies and commonly promote treatment resistance. This article provides a comprehensive overview of CSC signalling mechanisms, many of which have been shown to be regulated by POPDC1 in other cell types, thus suggesting an additional therapeutic benefit for POPDC1-stabilising anticancer drugs.

Peer review status:Published

18 Sep 2020Submitted to British Journal of Pharmacology
22 Sep 2020Submission Checks Completed
22 Sep 2020Assigned to Editor
05 Nov 2020Reviewer(s) Assigned
14 Dec 2020Review(s) Completed, Editorial Evaluation Pending
15 Dec 2020Editorial Decision: Revise Minor
13 Jan 20211st Revision Received
15 Jan 2021Submission Checks Completed
15 Jan 2021Assigned to Editor
15 Jan 2021Review(s) Completed, Editorial Evaluation Pending
16 Jan 2021Editorial Decision: Accept
03 Feb 2021Published in British Journal of Pharmacology. 10.1111/bph.15403