Association of maternal and cycle-related factors to pregnancy and
neonatal outcomes when excluding paternal factors by using donor sperm:
a retrospective cohort study
Abstract
Objective: Finding the maternal and cycle associated factors that affect
the pregnancy and neonatal outcomes when excluding paternal effect.
Design: A retrospective cohort study. Setting: Public fertility center.
Population: 1098 couples that received fresh IVF/ ICSI cycle with donor
sperm. Methods: The associations of maternal factors and cycle-related
parameters with pregnancy and neonatal outcomes were depicted as
adjusted odds ratios (aOR) / adjusted β and 95% confidence intervals
(CI). Main outcome measures: Pregnancy and neonatal outcomes. Results:
Women over 35 years had a distinctly decreased pregnancy and live birth
rate (aOR 0.904; 95% CI 0.317–2.584 and aOR 0.905; 95% CI
0.398–2.768). Abortion and multiple ART-cycles were linked with
increased risks of pregnancy failure, the oocyte retrieval and
transferred embryo numbers improved pregnancy incidence. Blastocyst
transfer increased both the probability of pregnancy and live birth (aOR
1.77; 95% CI 1.035–3.026 and aOR 1.364; 95% CI 1.041–1.788). For
newborn, the negative contribution of transferred embryo number to birth
weight and length was observed (adjusted β -0.30; 95% CI -0.533 to
-0.277 and adjusted β -0.197; 95% CI -0.789 to -0.332). Female BMI and
endometrial thickness both had a positive effect on birth weight and
length. Conclusions: Oocyte number, transferred embryo number, and
blastocyst transfer were positively associated with pregnancy or live
birth. Females over 35 had an abortion, and multiple ART cycles
experience linked to failure pregnancy. The transfer of multiple embryo
poses a threat to newborn body weight and length, while higher mother
BMI and endometrial thickness had positive influence.