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Bronchioloalveolar carcinoma arising in congenital pulmonary airway malformation in a neonate
  • +2
  • Gaia Vigano',
  • Matthew Thomas,
  • Corina Moldovan,
  • Laura Parnell,
  • Asif Hasan
Gaia Vigano'
Freeman Hospital
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Matthew Thomas
Royal Victoria Infirmary
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Corina Moldovan
Royal Victoria Hospital Division of Pathology
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Laura Parnell
Royal Victoria Infirmary
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Asif Hasan
Freeman Hospital Cardiothoracic Centre
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Abstract

Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation (CCAM), is a rare developmental lung abnormality with the potential for malignant transformation. Bronchioloalveolar carcinoma (BAC), pleuropulmonary blastoma (PPB), rhabdomyomatous dysplasia/rhabdomyosarcoma (RMS) have been associated with CPAM. We report an unusual case of a 1-day-old male newborn who underwent lobectomy for a cystic lung lesion, which was found to be a mucinous BAC with K-ras mutation in a type 1 CPAM. The case supports the relationship between type 1 CPAM and BAC/KRAS mutant, and highlights that the malignant transformation can occur in very early stage of the infancy.

Peer review status:Published

22 Sep 2020Submitted to Pediatric Pulmonology
23 Sep 2020Submission Checks Completed
23 Sep 2020Assigned to Editor
23 Sep 2020Reviewer(s) Assigned
09 Oct 2020Review(s) Completed, Editorial Evaluation Pending
09 Oct 2020Editorial Decision: Revise Minor
15 Nov 20201st Revision Received
18 Nov 2020Submission Checks Completed
18 Nov 2020Assigned to Editor
18 Nov 2020Reviewer(s) Assigned
19 Nov 2020Review(s) Completed, Editorial Evaluation Pending
20 Nov 2020Editorial Decision: Accept
May 2021Published in Pediatric Pulmonology volume 56 issue 5 on pages 1261-1263. 10.1002/ppul.25232