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Case report: Unusual Interaction Between Voriconazole and Ritonavir/Lopinavir in a COVID-19 Patient Due to CYP2C19 Gene Polymorphism
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  • Lifang Duan,
  • Qilin Pang,
  • Weixing Zhang,
  • Lei Huang
Lifang Duan
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Qilin Pang
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Weixing Zhang
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Abstract

Drug–drug interactions may be a serious issue for COVID-19-infected patients needed kinds of conminant medications. voriconazole and lopinavir/ritonavir were involved in interaction with cytochrome P450 enzymes, Therefore, coadministration of voriconazole and lopinavir/ritonavir is estimated to interfere the effect of voriconazole. However, the gene polymorphisms make these interactions more complicating.