“RNA + peptide editing are two successive independent mechanisms needed in order to make a panoply of new functional isoforms in a variety of binding protein families”. I present the specificities of ‘Chemosensory Proteins’ CSPs in insects and argue about their potential role in life origins and evolution. In particular, I address the relatedness of the observed mutations in insect CSPs to the origin of life. I describe the observed mutations in these CSPs in several insect species are occuring via various mechanisms, RNA editing and/or during protein synthesis, and propose that such mechanism could have been important in the emergence and evolution of life on the Earth’s crust.