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A Novel Finding in Pediatric Leiomyosarcoma: Expanding Spectrum of FGFR rearrangements in Childhood Cancers
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  • Yogindra Persaud,
  • Shruti Bagla,
  • Christina Shanti,
  • Bahig Shehata,
  • Yaddanapudi Ravindranath,
  • Hamza Gorsi
Yogindra Persaud
Children's Hospital of Michigan
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Shruti Bagla
Wayne State University
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Christina Shanti
Children's Hospital of Michigan
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Bahig Shehata
Children's Hospital of Michigan
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Yaddanapudi Ravindranath
Wayne State University
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Hamza Gorsi
Children's Hospital of Michigan
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Abstract

Non Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) are rare in the pediatric age group, accounting for 1-7% of all pediatric tumors. Leiomyosarcoma, a subtype of NRSTS, is exceedingly rare in pediatric population. Due to the rarity of this condition, management is extrapolated from other common NRSTS which involves surgery, chemotherapy and radiation. Chemotherapy is not very effective in management of pediatric leiomyosarcoma and molecular information may help guide targeted therapies. We describe a patient with a FGFR1-TACC1 gene rearrangement which, based on other models, predicts for sensitivity to FGFR inhibitors.

Peer review status:Published

16 Nov 2020Published in Pediatric Blood & Cancer. 10.1002/pbc.28805