Simultaneous intraocular and cutaneous extranodal NK/T cell lymphoma
refractory to multiple therapies including pembrolizumab
An 80 year old woman underwent vitrectomy for recurrent uveitis,
demonstrating lymphocytic vitreous fluid. Less than a month later skin
biopsy confirmed the diagnosis of extranodal NK/T cell lymphoma.
Chemotherapy with SMILE (steroid - dexamethasone, methotrexate,
ifosfamide, L-asparaginase, and etoposide) was poorly tolerated despite
reduced doses, while pembrolizumab was ineffective.