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Thiol-disulfide balance and total oxidant-antioxidant status in patients with chronic hepatitis C
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  • TUBA DAMAR ÇAKIRCA,
  • MEHMET REŞAT CEYLAN,
  • İsmail Koyuncu,
  • Gökhan Çakırca
TUBA DAMAR ÇAKIRCA
Şanlıurfa training and research hospital
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MEHMET REŞAT CEYLAN
Harran University
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İsmail Koyuncu
Harran University
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Gökhan Çakırca
Sanliurfa Mehmet Akif Inan Training and Research Hospital
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Abstract

Objective: Increasing evidences suggest that oxidative stress is closely related to the pathogenesis of hepatitis C virus (HCV) infection. The purpose of this study was to examine the dynamic thiol/disulfide homeostasis (DTDH) and total oxidant/antioxidant status in patients with HCV infection. Methods: Levels of serum total thiol (TT), native thiol (NT), disulfide (DS), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI; TOS/TAS ratio) as oxidative stress markers were determined in 162 individuals, including 74 patients with HCV infection and 88 non-HCV controls. Results: The NT, TT levels and NT/TT ratio were significantly lower and DS level, DS/NT and DS/TT ratios were significantly higher in HCV group compared to the control group. The TOS and OSI values were significantly higher and the TAS level was significantly lower in the HCV group than in the control group. No significant correlations were found between oxidative stress markers and albumin, alanine aminotransferase, aspartate aminotransferase and bilirubin levels in patients with HCV infection. A negative correlation was found only between OSI and albumin. Conclusion: These results indicate that patients with HCV infection are vulnerable to oxidative stress and have disturbed status of oxidant and antioxidant.

Peer review status:ACCEPTED

29 Sep 2020Submitted to International Journal of Clinical Practice
30 Sep 2020Submission Checks Completed
30 Sep 2020Assigned to Editor
01 Oct 2020Reviewer(s) Assigned
19 Oct 2020Review(s) Completed, Editorial Evaluation Pending
08 Nov 20201st Revision Received
10 Nov 2020Assigned to Editor
10 Nov 2020Submission Checks Completed
10 Nov 2020Reviewer(s) Assigned
10 Nov 2020Review(s) Completed, Editorial Evaluation Pending
19 Dec 20202nd Revision Received
21 Dec 2020Submission Checks Completed
21 Dec 2020Assigned to Editor
21 Dec 2020Reviewer(s) Assigned
29 Dec 2020Review(s) Completed, Editorial Evaluation Pending
03 Jan 2021Editorial Decision: Accept