loading page

Sex Differences in Opioid-Mediated Effects: Role of Androgens
  • Jessica Sharp,
  • Tallia Pearson,
  • Mark Smith
Jessica Sharp
Davidson College
Author Profile
Tallia Pearson
Davidson College
Author Profile
Mark Smith
Davidson College
Author Profile

Abstract

An abundance of data indicate there are sex differences in endogenous opioid peptides and opioid receptors, leading to functional differences in sensitivity to opioid-mediated behaviors between males and females. Many of these sex differences are mediated by the effects of gonadal hormones on the endogenous opioid system. Whereas much research has examined the role of ovarian hormones on opioid-mediated endpoints, comparatively less research has examined the role of androgens. This review describes what is currently known regarding the influence of androgens on opioid-mediated endpoints and how androgens may contribute to sex differences in opioid-mediated effects. The review also addresses the clinical implications of androgenic modulation of opioid-mediated behaviors and suggests future lines of research for preclinical and clinical investigators, We conclude that further investigation into androgenic modulation of opioid-mediated effects may lead to new options for addressing conditions such as chronic pain and substance use disorders.

Peer review status:IN REVISION

02 Oct 2020Submitted to British Journal of Pharmacology
02 Oct 2020Submission Checks Completed
02 Oct 2020Assigned to Editor
01 Nov 2020Reviewer(s) Assigned
26 Nov 2020Review(s) Completed, Editorial Evaluation Pending
09 Dec 2020Editorial Decision: Revise Minor
18 Feb 20211st Revision Received
22 Feb 2021Submission Checks Completed
22 Feb 2021Assigned to Editor
02 Mar 2021Reviewer(s) Assigned
15 Mar 2021Review(s) Completed, Editorial Evaluation Pending
24 Mar 2021Editorial Decision: Revise Minor
07 Apr 20212nd Revision Received
07 Apr 2021Submission Checks Completed
07 Apr 2021Assigned to Editor
22 Apr 2021Review(s) Completed, Editorial Evaluation Pending
23 Apr 2021Editorial Decision: Revise Minor
25 Apr 20213rd Revision Received
03 May 2021Assigned to Editor
03 May 2021Submission Checks Completed
04 May 2021Reviewer(s) Assigned
16 Jun 2021Review(s) Completed, Editorial Evaluation Pending
19 Jun 2021Editorial Decision: Revise Minor