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Effect of the ionic antineoplastic agent Cytoreg on blood chemistry in the Wistar rat model
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  • Katiusca Villasana,
  • William Quintero,
  • Yepsys Montero,
  • Cristian Pino,
  • Oscar Uzcátegui,
  • Geizon Torres,
  • Mariangel Prada,
  • Lewis Pozo,
  • William Bauta,
  • William Jimenez
Katiusca Villasana
University of the Andes
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William Quintero
University of the Andes
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Yepsys Montero
University of the Andes
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Cristian Pino
University of the Andes
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Oscar Uzcátegui
University of the Andes
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Geizon Torres
University of the Andes
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Mariangel Prada
University of the Andes
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Lewis Pozo
Cytorex Biosciences Inc
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William Bauta
Cytorex Biosciences Inc
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William Jimenez
Cytorex Biosciences Inc
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Abstract

Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo. Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not understood. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg increases oxygen levels and can be used from a therapeutic point of view.