Mechanisms of modulation of ferroptosis and its role in central nervous
Ferroptosis is a new form of programmed cell death characterized by
intracellular iron-dependent accumulation of lipid peroxide and
primarily associated with iron metabolism, glutathione-dependent
pathway, and Coenzyme Q10-dependent pathway. Recent studies demonstrate
that ferroptosis is associated with central nervous system (CNS)
diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and
Huntington’s disease. This review summarizes the key regulatory
mechanisms of modulation of ferroptosis and its role in CNS diseases.
These updates may provide novel prospective on therapeutical agent
developments against CNS diseases.