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Mechanisms of modulation of ferroptosis and its role in central nervous system diseases
  • Qingyun Tan,
  • Yuying Fang,
  • Qiong Gu
Qingyun Tan
Sun Yat-Sen University
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Yuying Fang
Sun Yat-Sen University
Author Profile
Qiong Gu
Sun Yat-Sen University
Author Profile

Abstract

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and Coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of modulation of ferroptosis and its role in CNS diseases. These updates may provide novel prospective on therapeutical agent developments against CNS diseases.