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Association between asthma and clinical mortality/morbidity in COVID-19 patients using clinical epidemiologic data from Korean Disease Control & Prevention
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  • Hyo Geun Choi,
  • Jee Hye Wee,
  • So Young Kim,
  • Joo-Hee Kim,
  • Hwan Il Kim,
  • Ji-Young Park,
  • Sunghoon Park,
  • Young Il Hwang,
  • Seung Hun Jang,
  • Ki-Suck Jung
Hyo Geun Choi
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Jee Hye Wee
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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So Young Kim
Bundang CHA Medical Center
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Joo-Hee Kim
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Hwan Il Kim
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Ji-Young Park
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Sunghoon Park
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Young Il Hwang
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Seung Hun Jang
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Ki-Suck Jung
Hallym University Sacred Heart Hospital, Hallym University College of Medicine
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Abstract

Background: The role of asthma as a risk factor for coronavirus 2019 (COVID-2019) morbidity and mortality is inconclusive and not fully understood. The primary objective was to evaluate the association between asthma history and mortality of COVID-19, and the secondary objective was to analyze the risk of COVID-19-related outcomes among patients with asthma compared to those without. Methods: Using clinical epidemiologic data from Korean Disease Control & Prevention, the risk for COVID-19-related morbidity and mortality were compared in patients with asthma and those without asthma among the participants who were confirmed to have COVID-19. A Cox proportional hazards regression model was used for mortality, and a linear regression model was used for morbidity scores. Results: The hazard ratio for death of patients with asthma versus those without was 2.48 (95% confidence interval (CI) 1.21-5.08, P=0.013) and 2.20 (95% CI 1.02-4.76, P=0.045) after full adjustment. The comorbidity of asthma was associated with an increase in the maximal morbidity score of COVID-19 compared to no asthma (estimated value of morbidity score (EV) = 0.44, 95% CI 0.16-0.73, P=0.003). Conclusion: Asthma is associated with an increased risk of mortality and morbidity in the Korean nationwide COVID-19 registry.

Peer review status:Published

10 Dec 2020Published in Allergy. 10.1111/all.14675