loading page

A Multicenter Study of Three-dimensional Echocardiographic Evaluation of Normal Pediatric Left Ventricular Volumes and Function with Automated Versus Semi-Automated Quantification
  • +8
  • Pei-Ni Jone,
  • Lisa Le,
  • Zhaoxing Pan,
  • Tim Colen,
  • Sachie Shigemitsu,
  • Nee Scze Khoo,
  • Benjamin Goot,
  • Anitha Parthiban,
  • David Harrild,
  • Alessandra Ferraro,
  • Gerald Marx
Pei-Ni Jone
Children's Hospital Colorado
Author Profile
Lisa Le
Children's Hospital Colorado
Author Profile
Zhaoxing Pan
University of Colorado Denver Children's Hospital Colorado Research Institute
Author Profile
Tim Colen
Stollery Children's Hospital
Author Profile
Sachie Shigemitsu
Stollery Children's Hospital
Author Profile
Nee Scze Khoo
Stollery Children's Hospital
Author Profile
Benjamin Goot
Childrens Wisconsin
Author Profile
Anitha Parthiban
Children's Mercy Hospitals and Clinics
Author Profile
David Harrild
Boston Children's Hospital
Author Profile
Alessandra Ferraro
Boston Children s Hospital
Author Profile
Gerald Marx
Boston Children's Hospital
Author Profile

Abstract

Background: Three-dimensional echocardiography (3DE) evaluation of left ventricular (LV) volume and function in pediatrics compares favorably with cardiac magnetic resonance imaging. A multicenter trial with automated and semi-automated LV quantification allows for generation of normative data in large pediatric patients. The aims of this study were to evaluate the feasibility and reproducibility of measuring three-dimensional echocardiography (3DE) volumes and function in pediatric patients in a multicenter trial; to determine if automated software (without contouring edits) will improve the reproducibility in volume and function analysis; and thus establish normal z score values in this unique population. Methods: Six hundred and ninety-eight healthy children (ages 0 to 18 years) were recruited from 5 centers. Left ventricular (LV) 3DE was acquired from the 4-chamber view. A vendor independent software analyzed end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) using automated and semi-automated quantification. Feasibility and reproducibility were assessed. Body surface area (BSA) based z-scores were generated. Results: Feasibility was 79% (523/658). Reproducibility was good between centers using the semi-automated quantification. Reproducibility was decreased using the automated quantification. Therefore, Z-scores were generated for ESV, EDV, and SV using the semi-automated method. Conclusions: 3DE can reliably evaluate LV volumes and EF in pediatric patients at different centers. We report pediatric Z-scores for normal LV volumes using the semi-automated method. Further optimization of technology will be necessary for reliable use of fully automated quantification by 3DE in children.